Hsieh, Y. Experimental Design Thirty rats were randomly distributed in 5 groups each: Khan and J. See also: This finding also corroborate important alterations found in the extracellular matrix in the groups that received wistar rats diet and high-fat diet, since these components may occupy regions of the tissue that should be filled by collagen, leading to an inefficient deposition of fibers and consequently the formation of a thin, fragile scar.
Teixeira, L. Discussion Our results suggest that a high-fat diet and alcohol intakes contributed to alterations in the connective tissue, inducing biochemical alterations that prevented proper tissue reconstruction within 21 days, and therefore impairing skin contraction and wound healing.
Fibroblasts are the main cells involved with collagen III-rich granulation tissue, which is gradually replaced by the more resistant collagen I [ 78 ].
Concentration-response curves to ACh in arterial segments from the same animal that previously received only vehicle distilled water were considered as controls for the evaluation of the effects of these treatments.
Curtis, S. Odagiri, C. The name was originally hyphenated, although the brand styling today Sprague Dawley, the trademark used by Envigo is not.
Soluble sugars were determined by ion chromatography using the method described by Colina-Coca et al. Toluidine blue, bar: However, the cellular and molecular mechanism s underlying these basic defects is not clear yet.
Our results showed that the administration of a combined high-fat diet and alcohol delayed type I and type III collagen deposition, impairing cell migration and fiber synthesis and remodeling. The lack of this organ severely compromises their immune system, infections of the respiratory tract and eye increasing the most dramatically.
Souza, E. Blood samples were then centrifuged at for 10 min, and the serum was reserved for the levels of triglyceride analyses, glucose, alanine aminotransferase ALTand aspartate aminotransferase AST.
Halliwell and J. However, when the effect of an aggressive agent is markedly intense, the antioxidant systems might not be able to neutralize the harmful ROS production and the tissues might present morphological and functional alterations that delay the healing process.
Given the growing body of evidence demonstrating the prominent role of gut microbiota in energy balance and metabolism, the gut microbiota composition and its modulation by HF diet were also evaluated in both strains.
Louis, Missouri, USA [ 22 ]. The wound area was previously marked with the use of crystal violet and measured with the use of an analog caliper Mitutoyo Ltd. Dieterich, U. Figure 7: Its phenotype is similar to the widely researched reeler mouse.
In our study, the excess production of reactive species of thiobarbituric acid malondialdehyde and protein carbonyls showed a negative effect of combining a high-fat diet and alcohol on skin repair.Supplementation with low doses of CoQ10 failed to increase the maximum life span potential of rats fed a V or F diet.
No clear evidence showing that monounsaturated fatty acids, n-3 polyunsaturated fatty acids, or CoQ10 exerted the observed effects by modulating the rate of aging has been found.
Wistar or Sprague-Dawley male rats were fed ad libitum a standard diet (ST-1, 10 % kcal fat), a medium-fat gelled diet (MFGD, 35 % kcal fat) and a high-fat gelled diet (HFGD, 71 % kcal fat) for 3 or 6.
· Wistar rats fed with HF diet consumed higher amounts of food (data not shown) and, therefore, higher amounts of energy throughout the study when compared to SD rats fed with the same diet.
Consequently, weight gain was larger in these animals and was mainly due to an expansion of adipose tissue festival-decazeville.comon: Rockville Pike, Bethesda, MD.
· Male Wistar rats fed a normal laboratory pelleted diet, when treated s.c. with 1,2-dimethylhydrazine (DMH) 10 mg/kg/wk survived the week experiment, showed no Cited by: 7. The Wistar rat is currently one of the most popular rats used for laboratory research.
It is characterized by its wide head, long ears, and a tail length that is always less than its body length. The Sprague Dawley rat and Long–Evans rat were developed from Wistar rats.
Wistar rats are more active than others like Sprague Dawley rats. · High-cholesterol diet enriched with onion affects endothelium-dependent relaxation and NADPH oxidase activity in mesenteric microvessels from Wistar rats.